Articles

Exosomes secreted by chemoresistant ovarian cancer cells promote angiogenesis

Ovarian cancer (OC) has the highest mortality rate in gynecologic tumors. Despite decades of continuous efforts, the survival rate of patients has not improved significantly, mostly due to drug resistance. Exo...

Authors: Zhang Li, Wang Yan-qing, Yang Xiao, Liu Shi-yi, Yuan Meng-qin, Xian Shu, Yang Dong-yong, Zheng Ya-jing and Cheng Yan-xiang

Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer

Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H ant...

Authors: Xiaolei Yuan, Ying Huang, Man Guo, Xiaowei Hu and Peiling Li

Evaluation of safety, feasibility and efficacy of intra-ovarian transplantation of autologous adipose derived mesenchymal stromal cells in idiopathic premature ovarian failure patients: non-randomized clinical trial, phase I, first in human

Premature ovarian failure (POF) is characterized by the loss of ovarian activity before the age of 40 years. Stem cell therapy has the capability to create a regenerative microenvironment and is a proposed tre...

Authors: M. Mashayekhi, E. Mirzadeh, Z. Chekini, F. Ahmadi, P. Eftekhari-Yazdi, S. Vesali, T. Madani and N. Aghdami

Berberine inhibited metastasis through miR-145/MMP16 axis in vitro

Ovarian cancer is the first leading cause of death in gynecological cancers. The continuous survival and metastasis of cancer cells are the main causes of death and poor prognosis in patients with ovarian canc...

Authors: Jie Li, Songlin Zhang, Lei Wu, Meili Pei and Yu Jiang

A flexible short protocol in women with poor ovarian response over 40 years old

Ovarian responsiveness to controlled ovarian stimulation is essential for a successful clinical outcome in assisted reproductive technology (ART) cycles. We aimed to find a suitable new ovulation stimulation p...

Authors: Xinyue Zhang, Ting Feng, Jihong Yang, Yingying Hao, Suying Li, Yan Zhang and Yun Qian

Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer

To assess the clinical value of early clearance of HE4 and CA125 for platinum sensitivity and prognosis in patients with ovarian cancer.

Authors: Yan Rong and Li Li

Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes play important roles in folliculogenesis. Altered expression of the two have been found among patients with poor ovarian resp...

Authors: Yan Gong, Jesse Li-Ling, Dongsheng Xiong, Jiajing Wei, Taiqing Zhong and Hao Tan

RETRACTED ARTICLE: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

Although lncRNA CTBP1-AS2 has been functionally analyzed only in cardiomyocyte hypertrophy and diabetes, analysis of TCGA dataset revealed its downregulation in endometrial carcinoma (EC), indicating its invol...

Authors: Qing-an-zi Wang, Yongxiu Yang and Xiaolei Liang

Retraction Note: LncRNA CTBP1-AS2 sponges miR-216a to upregulate PTEN and suppress endometrial cancer cell invasion and migration

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13048-020-00754-0.

Authors: Qing-an-zi Wang, Yongxiu Yang and Xiaolei Liang

Germline variation of Ribonuclease H2 genes in ovarian cancer patients

Epithelial ovarian carcinoma (EOC) is a genetically heterogeneous disease that is partly driven by molecular defects in mismatch repair (MMR) or homology-directed DNA repair (HDR). Ribonuclease H2 serves to re...

Authors: Rahel Polaczek, Peter Schürmann, Lisa-Marie Speith, Robert Geffers, Matthias Dürst, Peter Hillemanns, Tjoung-Won Park-Simon, Clemens Liebrich and Thilo Dörk

LncRNA GAS5 is upregulated in polycystic ovary syndrome and regulates cell apoptosis and the expression of IL-6

GAS5 contains a hormone response element that can induce cell apoptosis in breast cancer. It is known that cell apoptosis and hormone response play crucial roles in polycystic ovary syndrome (PCOS), indicating...

Authors: Chunxia Wang, Shishi Yue, Yaru Jiang, Yanjia Mao, Zhijing Zhao, Xinwei Liu, Xiaoqian Zhang, Dongxu Pei and Yongwei Li

Dysregulation of lnc-SNHG1 and miR-216b-5p correlate with chemoresistance and indicate poor prognosis of serous epithelial ovarian cancer

This study aimed to explore whether the dysregulation of lnc-small nucleolar RNA host gene 1 (SNHG1) and miR-216b-5p correlated with chemoresistance and indicated poor prognosis of serous epithelial ovarian ca...

Authors: Mei Li Pei, Zong Xia Zhao and Ting Shuang

Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report

Patients with ovarian clear cell carcinoma (OCCC) have a poor prognosis because they show low sensitivity to platinum-based chemotherapy. New treatments for refractory OCCC are urgently needed.

Authors: Yu-Chien Lin, Kuo-Chang Wen, Pi-Lin Sung, Yu-Ting Chou, Phui-Ly Liew, Lin-Yu Chen, Rui-Lan Huang, Hung-Cheng Lai and Lu-Te Chang

Ovarian fibrosarcoma: A single-institution experience and a review of the literature

Ovarian fibrosarcoma is an extremely rare and malignant sex cord-stromal tumor. Due to its low incidence and poor prognosis, until now, very few cases have been reported, and most of the reported cases have be...

Authors: Ting-Ting Sun, Ning-Hai Cheng, Dong-Yan Cao and Peng Peng

Improved prognosis for recurrent epithelial ovarian cancer by early diagnosis and 125I seeds implantation during suboptimal secondary cytoreductive surgery: a case report and literature review

Epithelial ovarian cancer (EOC) has the worst prognosis in all of gynecologic malignant tumors because of its high recurrence and eventually chemo-resistance. Early diagnosis of recurrence is crucial to avoid ...

Authors: Lin Xiao, Junying Tang, Wenbo Li, Xuexun Xu and Hao Zhang

A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public h...

Authors: Mitko Madjunkov, Michal Dviri and Clifford Librach

Transferrin and antioxidants partly prevented mouse oocyte oxidative damage induced by exposure of cumulus-oocyte complexes to endometrioma fluid

Exposure of oocytes to the endometrioma fluid has an adverse effect on embryonic quality. To determine whether adding transferrin and antioxidants to culture medium could counteract detrimental effects on mous...

Authors: Zi Ren, Jiana Huang, Chuanchuan Zhou, Lei Jia, Manchao Li, Xiaoyan Liang and Haitao Zeng

Chemoprotective effects of plasma derived from mice of different ages and genders on ovarian failure after cyclophosphamide treatment

Premature ovarian failure is one of the major side effects of chemotherapy drugs. Blood plasma contains several factors that might lead to the repair of different tissues.

Authors: Soghra Bahmanpour, Eisa Moradiyan, Farzaneh Dehghani and Nehleh Zarei-fard

Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age

Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a ...

Authors: Jacob O’Brien, Kevin Y. Du and Chun Peng

Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro

Genetic causes of premature ovarian insufficiency (POI) account for approximately 20 ~ 25% of patients. So far, only a few genes have been identified.

Authors: Xuzi Cai, Huijiao Fu, Yan Wang, Qiwen Liu and Xuefeng Wang

STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells

In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia. Many studies have implicated the e...

Authors: Yao Jiang, Xiaoping Xin, Xiangchun Pan, Ailing Zhang, Zhe Zhang, Jiaqi Li and Xiaolong Yuan

Knowledge of iatrogenic premature ovarian insufficiency among Chinese obstetricians and gynaecologists: a national questionnaire survey

With increasing cases of iatrogenic premature ovarian insufficiency (POI), more clinicians are required to counsel patients regarding the gonadotoxic effects of iatrogenic treatments. This survey aimed to expl...

Authors: Yanfang Wang, Ying Zou, Wei Wang, Qingmei Zheng, Ying Feng, Han Dong, Zhangyun Tan, Xiaoqin Zeng, Yinqing Zhao, Danhong Peng, Xiaomin Yang and Aijun Sun

Correction to: Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Zixuan Gao, Xiaochen Ma, Jing Liu, Yuhang Ge, Lei Wang, Ping Fu, Zhian Liu, Ruiqin Yao and Xiaonan Yan

Possibility of live birth in patients with low serum β-hCG 14 days after blastocyst transfer

Although prior work has attempted to predict pregnancy outcomes by assaying serum β-hCG levels after blastocyst transfer, no study has focused on pregnancy outcomes in those with initially low serum β-hCG leve...

Authors: Yixuan Wu and Haiying Liu

Identification of an autophagy-related gene signature for survival prediction in patients with cervical cancer

Cervical cancer is one of the most common female malignancy that occurs worldwide and is reported to cause over 300,000 deaths in 2018. Autophagy controls the survival and death of cancerous cells by regulatin...

Authors: Hengyu Chen, Qingchun Deng, Wenwen Wang, Huishan Tao and Ying Gao

Therapeutic role of curcumin and its novel formulations in gynecological cancers

Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerabl...

Authors: Mohammad Hossein Pourhanifeh, Maryam Darvish, Javad Tabatabaeian, Mahboobeh Rabbani Fard, Reza Mottaghi, Mohammad Javad Azadchehr, Moghaddaseh Jahanshahi, Amirhossein Sahebkar and Hamed Mirzaei

Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases

Ovarian carcinosarcomas (OCS) are very rare tumors composed of a mixture of carcinomatous and sarcomatous elements. There have been only scattered case studies that have described the imaging findings. In orde...

Authors: Qiong Xu, Xiaofei Zhang and Yu Zou

Ovarian metastasis from nongynecologic primary sites: a retrospective analysis of 177 cases and 13-year experience

Metastasis to the ovary from nongynecologic organs accounts for 9% of all ovarian malignancies. Although the most common nongynecologic primary site of ovarian metastasis is the gastrointestinal tract, metasta...

Authors: Jing-Jing Zhang, Dong-Yan Cao, Jia-Xin Yang and Keng Shen

Long non-coding RNA PTPRG-AS1 promotes cell tumorigenicity in epithelial ovarian cancer by decoying microRNA-545-3p and consequently enhancing HDAC4 expression

Long non-coding RNA PTPRG antisense RNA 1 (PTPRG-AS1) deregulation has been reported in various human malignancies and identified as an important modulator of cancer development. Few reports have focused on th...

Authors: Juanjuan Shi, Xijian Xu, Dan Zhang, Jiuyan Zhang, Hui Yang, Chang Li, Rui Li, Xuan Wei, Wenqing Luan and Peishu Liu

Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells

This study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells.

Authors: Jun Gao, Yao Gao, Shixin Lin, Xia Zou, Yukai Zhu, Xintong Chen, Hong Wan and Hong Zhu

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests tumor-supporting roles of several members of the kallikrein-related peptida...

Authors: Weiwei Gong, Yueyang Liu, Eleftherios P. Diamandis, Marion Kiechle, Holger Bronger, Julia Dorn, Tobias Dreyer and Viktor Magdolen

Prediction of the treatment response in ovarian cancer: a ctDNA approach

Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular mar...

Authors: Mina Sharbatoghli, Somayeh Vafaei, Hamidreza Aboulkheyr Es, Mohsen Asadi-Lari, Mehdi Totonchi and Zahra Madjd

Development and validation of Nomograms for predicting overall survival and Cancer-specific survival in patients with ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is a rare histologic type of ovarian cancer. There is a lack of an efficient prognostic predictive tool for OCCC in clinical work. This study aimed to construct and validate...

Authors: Qian Chen, Shu Wang and Jing-He Lang

LINC01094/miR-577 axis regulates the progression of ovarian cancer

Long intergenic non-coding RNA 01094 (LINC01094) is probably a novel regulator in cancer biology. This study aimed to probe into the function and mechanism of LINC01094 in ovarian cancer (OC).

Authors: Jing Xu, Ping Zhang, Huajun Sun and Yang Liu

Comparison of methods for quantifying primordial follicles in the mouse ovary

Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ...

Authors: Urooza C. Sarma, Amy L. Winship and Karla J. Hutt

Bioinformatics analysis of prognostic value and prospective pathway signal of miR-30a in ovarian cancer

MicroRNAs (MiRNAs) is thought to play a critical role in the initiation and progress of ovarian cancer (OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in.....

Authors: Weijia Lu, Yunyu Wu, Can Xiong Lu, Ting Zhu, Zhong Lu Ren and Zhiwu Yu

Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer

Wilms tumor 1 associated protein (WTAP) modulates other genes via transcriptional and post-transcriptional regulation, in particular, by acting as a N6-methyladenosine writer or binding to the 3’UTR of mRNA, a...

Authors: Jing Wang, Jing Xu, Ke Li, Yunke Huang, Yilin Dai, Congjian Xu and Yu Kang

Patient with ovarian insufficiency: baby born after anticancer therapy and re-transplantation of cryopreserved ovarian tissue

The second major cause of death is cancer. In fact, the effectiveness of anticancer treatments and positive long-term prognosis for young women has increased. However, the problem of post-cancer infertility pl...

Authors: Vladimir Isachenko, Bernd Morgenstern, Plamen Todorov, Evgenia Isachenko, Peter Mallmann, Bettina Hanstein and Gohar Rahimi

Predicting complete cytoreduction for advanced ovarian cancer patients using nearest-neighbor models

The foundation of modern ovarian cancer care is cytoreductive surgery to remove all macroscopic disease (R0). Identification of R0 resection patients may help individualise treatment. Machine learning and AI h...

Authors: Alexandros Laios, Alexandros Gryparis, Diederick DeJong, Richard Hutson, Georgios Theophilou and Chris Leach

Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches

Ovarian cancer is the second fatal malignancy of the female reproductive system. Based on the cancer stem cell (CSC) theory, its poor prognosis of ovarian cancer attributed to tumor recurrence caused by CSCs. ...

Authors: Xiaoxiao Zhang, Yue Su, Xue Wu, Rourou Xiao, Yifan Wu, Bin Yang, Zhen Wang, Lili Guo, Xiaoyan Kang and Changyu Wang

Adipocytes: active facilitators in epithelial ovarian cancer progression?

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflam...

Authors: Lan Dai, Keqi Song and Wen Di

Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention

The loss of ovarian function in women, referred to as premature ovarian insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically heterogeneous, and in most cases, the etiolo...

Authors: Hongli Liu, Xiaoli Wei, Yanwei Sha, Wensheng Liu, Haijie Gao, Jin Lin, Youzhu Li, Yaling Tang, Yifeng Wang, Yanlong Wang and Zhiying Su

RETRACTED ARTICLE: The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer

To assess the anti-tumor activity and side effects of different dosages of paclitaxel (albumin binding type) (hereinafter referred to as nab-P) combined with Apatinib (hereinafter referred to as AP) in platinu...

Authors: Hong Zhao, Rong Li, Xiaoyan Wang, Xin Lu, Min Hu, Jinbin Zhang, Xia Zhao, Xiaoqin Song and Yangyang Liu

A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy

In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gyn...

Authors: Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yiyu Han, Qian Li, Qin Zou, Zhongpei Zhang, Jin Huang and Qingchun Deng

YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis, and migration in ovarian cancer cells

RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epi...

Authors: Jie Li, Lei Wu, Meili Pei and Yun Zhang

microRNA-1271-5p/TIAM1 suppresses the progression of ovarian cancer through inactivating Notch signaling pathway

Ovarian cancer (OC) has been regarded as the most malignant gynecological neoplasm and often confers grave outcomes owing to the frequent metastasis and high recurrence. A previous study has demonstrated that ...

Authors: Feng-Juan Han, Jia Li, Ying Shen, Ying Guo, Yi-Chao Liu, Yang Yu, Jia-Yue Xu, Shao-Xuan Liu and Yan-Hong Wang

Degenerated oocyte in the cohort adversely affects IVF outcome

The presence of Degenerated Oocyte (DEG) was mostly described after intracytoplasmic sperm injection (ICSI), with fewer reports on DEG at the time of ovum pick-up (OPU). This study aims to assess morphokinetic...

Authors: Yuval Atzmon, Mediea Michaeli, Diana Poltov, Nechami Rotfarb, Oshrit Lebovitz, Nardin Aslih and Einat Shalom-Paz

Effect of animal-sourced bioactive peptides on the in vitro development of mouse preantral follicles

The aim of this study was to investigate the effect of bioactive peptides (BAPT) from animal sources on the development of mouse preantral follicles in vitro. Preantral follicles were isolated and randomly div...

Authors: Gang Liu, Shubin Li, Jinyu Ren, Chunyu Wang, Yaxuan Zhang, Xiulan Su and Yanfeng Dai

High preoperative serum sVCAM-1 concentration as a predictor of early ovarian cancer recurrence

Authors: Marina Jakimovska, Katarina Černe, Ivan Verdenik and Borut Kobal

Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

The exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammati...

Authors: Zixuan Gao, Xiaochen Ma, Jing Liu, Yuhang Ge, Lei Wang, Ping Fu, Zhian Liu, Ruiqin Yao and Xiaonan Yan