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|
Variant
|
Genetic model
|
Parameter
|
study(N)
|
sample size (N)
|
Overall effect
|
|
MD
|
95% CI
|
I2(%)
|
P
|
|
AMH (rs10407022)
|
Dominant (TT versus GG/GT)
|
Gn dosage
|
4
|
1448
|
11.75
|
−38.70, 62.20
|
17
|
0.65
|
|
stimulation duration
|
3
|
907
|
0.07
|
−0.16, 0.31
|
37
|
0.53
|
|
oocytes retrieved
|
6
|
1723
|
−0.19
|
−1.29, 0.91
|
81
|
0.73
|
|
MII oocytes
|
2
|
787
|
1.20
|
0.76, 1.65
|
0
|
<0.00001
|
|
Homozygote (TT versus GG)
|
Gn dosage
|
2
|
687
|
215.22
|
−142.04, 572.47
|
86
|
0.24
|
|
oocytes retrieved
|
3
|
792
|
0.25
|
−2.70, 3.21
|
93
|
0.87
|
|
MII oocytes
|
2
|
423
|
1.68
|
0.35, 3.01
|
70
|
0.01
|
|
Heterozygote (TT versus GT)
|
Gn dosage
|
2
|
1052
|
−35.47
|
−74.68, 3.74
|
0
|
0.08
|
|
oocytes retrieved
|
3
|
1199
|
−0.27
|
−1.66, 1.12
|
88
|
0.71
|
|
MII oocytes
|
2
|
676
|
1.2
|
0.74, 1.66
|
0
|
<0.00001
|
|
Recessive (GG versus TT/GT)
|
Gn dosage
|
2
|
1335
|
−0.42
|
−2.69, 1.85
|
90
|
0.72
|
|
oocytes retrieved
|
2
|
679
|
−0.42
|
−2.69, 1.85
|
90
|
0.72
|
|
MII oocytes
|
2
|
787
|
−1.22
|
−3.00, 0.55
|
88
|
0.18
|
|
AMHR2 (rs2002555)
|
Dominant (AA versus GG/AG)
|
Gn dosage
|
4
|
1230
|
−13.25
|
− 109.45, 82.95
|
63
|
0.79
|
|
Stimulation duration
|
3
|
907
|
2.81
|
−4.51, 10.13
|
100
|
0.45
|
|
oocytes retrieved
|
5
|
1614
|
0.01
|
−0.81, 0.83
|
66
|
0.97
|
|
MII oocytes
|
2
|
787
|
−0.02
|
− 0.52, 0.49
|
4
|
0.95
|
|
Variant
|
Genetic model
|
Parameter
|
study(N)
|
sample size (N)
|
Overall effect
|
|
MD
|
95% CI
|
I2(%)
|
P
|
|
AMHR2 (rs2002555)
|
Homozygote (AA versus GG)
|
Gn dosage
|
2
|
631
|
− 150.35
|
− 319.02, 18.32
|
0
|
0.08
|
|
oocytes retrieved
|
3
|
969
|
0.32
|
−1.34, 1.99
|
73
|
0.70
|
|
MII oocytes
|
2
|
571
|
0.22
|
−1.98, 2.42
|
82
|
0.85
|
|
Heterozygote (AA versus AG)
|
Gn dosage
|
2
|
928
|
52.37
|
−73.00, 177.75
|
74
|
0.41
|
|
oocytes retrieved
|
4
|
1587
|
−0.41
|
−1.31, 0.48
|
67
|
0.36
|
|
MII oocytes
|
2
|
756
|
−0.05
|
− 0.55, 0.45
|
0
|
0.84
|
|
Recessive (GG versus AA/AG)
|
Gn dosage
|
2
|
958
|
147.15
|
−19.30, 313.60
|
0
|
0.08
|
|
oocytes retrieved
|
3
|
1342
|
−0.36
|
−2.24, 1.53
|
80
|
0.71
|
|
MII oocytes
|
2
|
787
|
−0.27
|
−2.27, 1.73
|
80
|
0.79
|
- MD: mean difference; CI: confidence interval; P: p value for association with significance set at < 0.05; I2 values as measure of heterogeneity are considered low (< 50%), moderate (51–74%) or high (> 75%); values in bold indicate significant associations;
